What is Sorsby's fundus dystrophy?

What is Sorsby's fundus dystrophy?

TIMP-3 mRNA is not overexpressed in Sorsby fundus dystrophy.

PURPOSE To assess the expression of MMP (matrix metalloproteinase)-2 and -9 and TIMP (tissue inhibitors of metalloproteinases)-1, -2, and -3 in Sorsby fundus dystrophy. DESIGN Cliniciopathological report. METHODS A donor eye with a confirmed S181C mutation in the TIMP-3 gene and an age-matched normal donor eye were studied using in situ hybridization technique with MMP -2 and -9 and TIMP -1...

P-value: What is and what is not

The misinterpretation and misuse of p-value have been increasing for decades. In March 2016, the American Statistical Association released a statement to warn about the use and interpretation of p-value. In this study, we provided a definition and discussion of p-value and emphasized the importance of its accurate interpretation.    

A mouse model for Sorsby fundus dystrophy.

PURPOSE Sorsby fundus dystrophy (SFD) is a rare, late-onset macular dystrophy caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. The known mutations introduce potentially unpaired cysteine residues in the C terminus of the protein and result in the formation of higher-molecular-weight protein complexes of as yet unknown composition and functional consequences in t...

What Is Applied Literature?

Applied literature is a term that is the outcome of a need to put literature to tangible uses in the “real” world. A medical practitioner looking for a definition of life, for instance, finds literature a useful source for the answer. With paradigm shifts in scientific studies, interdisciplinarity has been a method to overcome the alienations that resulted from the isolation of disciplines from...